A patient with primary hypothyroidism and pituitary gland enlargement was studied extensively before and after replacement therapy with levothyroxine sodium. She had evidence of bulging of the diaphragma sellae and increased serum prolactin levels. Thyroid replacement therapy resulted in regression of the pituitary size, as shown on pneumoencephalogram, but mildly elevated serum prolactin levels persisted.
(Arch Intern Med 138:1555-1557, 1978)
Jawadi MH, Ballonoff LB, Stears JC, Katz FH. Primary Hypothyroidism and Pituitary EnlargementRadiological Evidence of Pituitary Regression. Arch Intern Med. 1978;138(10):1555–1557. doi:10.1001/archinte.1978.03630350079021
Customize your JAMA Network experience by selecting one or more topics from the list below.