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November 1978

Acute Promyelocytic Leukemia: Management of the Coagulopathy During Daunorubicin-Prednisone Remission Induction

Author Affiliations

From the Section of Medical Oncology (Drs Collins, Bloomfield, and Peterson), and the Department of Laboratory Medicine and Pathology (Drs McKenna and Edson), University of Minnesota Health Sciences Center, Minneapolis.

Arch Intern Med. 1978;138(11):1677-1680. doi:10.1001/archinte.1978.03630360059024

Seven adults with acute promyelocytic leukemia (APL) and disseminated intravascular coagulation were treated for remission induction with daunorubicin hydrochloride and prednisone. In all patients the coagulopathy was managed with continuous-infusion heparin sodium and vigorous transfusion with platelets, cryoprecipitate, and fresh frozen plasma. Five patients survived induction; they all achieved complete remission (CR). Median duration of CR was 27+ months; two patients presently survive in their initial CR at 28 and 48 months. Recognition of APL as a distinct type of acute leukemia and prompt initiation of treatment aimed at rapid cytoreduction and control of the coagulopathy has resulted in a prolonged disease-free survival for the majority of patients.

(Arch Internal Med 138:1677-1680, 1978)