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November 1978

The Syndrome of Inappropriate Antidiuretic Hormone Secretion in Multiple Sclerosis

Author Affiliations

From the Department of Medicine, Division of Metabolism (Drs Apple and Kreines), and Department of Neurology (Dr Biehl), University of Cincinnati College of Medicine.

Arch Intern Med. 1978;138(11):1713-1714. doi:10.1001/archinte.1978.03630360089034

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) occurred during an excerbation of multiple sclerosis (MS). Rapid symptomatic improvement occurred with correction of the hyponatremia. Although the pathophysiology responsible for development of the SIADH in this patient is unknown, CNS involvement by MS is a likely explanation.

(Arch Intern Med 138:1713-1714, 1978)