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February 1979

The Limited Utility of Fibrinogen I 125 Leg Scanning

Arch Intern Med. 1979;139(2):143. doi:10.1001/archinte.1979.03630390009004

Elsewhere in this issue of the Archives (see p 148) is an article on the limitations of the use of fibrinogen I 125 leg scanning in the diagnosis of lower extremity deep venous thrombosis. The well-controlled clinical study outlined therein helps put into perspective the actual limitations of the leg scan technique, since it shows the lack of correlation between clotting documented by the use of leg scanning and clotting demonstrated by venography. This lack of correlation is in direct opposition to previous study results, which apparently showed an excellent correlation between leg scan and venogram clotting. As established by many others, the leg scan is unreliable when used in the upper one third of the thigh; but surprisingly, this study showed that the scan was also inaccurate in the calf area (50% positive accuracy, 84% negative accuracy). The authors of the present article point out that most series previously

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