A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed. Clinical recovery followed discontinuation of therapy and paralleled EEG resolution. This complication was dose related and argues for caution when initiating intrathecal therapy with amphotericin B at doses greater than 0.025 mg.
(Arch Intern Med 139:706-707, 1979)
Winn RE, Bower JH, Richards JF. Acute Toxic DeliriumNeurotoxicity of Intrathecal Administration of Amphotericin B. Arch Intern Med. 1979;139(6):706–707. doi:10.1001/archinte.1979.03630430082027