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July 1979

Hydrochlorothiazide-Induced Pulmonary Edema: Report of a Case and Review of the Literature

Author Affiliations

From the Pulmonary Disease Section, Albert Einstein Medical Center (Drs Bell and Lippmann), and the Department of Medicine, Temple University School of Medicine (Dr Lippmann), Philadelphia.

Arch Intern Med. 1979;139(7):817-819. doi:10.1001/archinte.1979.03630440075024

Immediately following the initial ingestion of hydrochlorothiazide, acute pulmonary edema developed in a patient who previously used bendroflumethiazide. Unlike previously published reports, we studied the patient from immunologic and pulmonary function aspects. Using standard techniques, no significant immunological mechanisms could be demonstrated. The pulmonary function testing disclosed a widened alveolararterial oxygen gradient and mildly decreased diffusing capacity that cleared on serial testing. We believe that this demonstrates a rare idiosyncratic reaction that apparently is seen specifically with hydrochlorothiazide and not with other thiazide medications.

(Arch Intern Med 139:817-819, 1979)