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September 1979

Results of Parathyroidectomy for Autonomous Hyperparathyroidism

Author Affiliations

From the Departments of Surgery and Medicine, the University of Texas Medical Branch, Galveston.

Arch Intern Med. 1979;139(9):989-991. doi:10.1001/archinte.1979.03630460029012

Autonomous hyperparathyroidism occurred in 15% of 152 patients maintained by long-term home dialysis during the past nine years. Twenty-two patients with elevated serum parathormone levels and progressive bone disease in the presence of normal serum phosphate and calcium levels were treated by subtotal parathyroidectomy. All had parathyroid hyperplasia. Eighteen of the 22 patients are presently alive and undergo dialysis. Symptoms of bone pain, pruritus, and muscle cramps had improved in three fourths of the patients. The serum parathormone level decreased from a preoperative average of 576 μLEq/mL to an average of 188 μLEq/mL postoperatively. All 18 patients, observed for six to 77 months, showed improvement in x-ray films of their bone disease. The autonomous hyperparathyroidism of end-stage renal disease is corrected by subtotal parathyroidectomy, and the effect is sustained.

(Arch Intern Med 139:989-991, 1979)