Multiple epithelial malignant neoplasms developed in two patients with Hodgkin's disease subsequent to radiotherapy and intensive chemotherapy. At the time of diagnosis, each patient also demonstrated a serum immunoglobulin deficiency. The significance of the occurrence of solid tumors in patients following therapy for Hodgkin's disease and the significance of cellular and humoral immunodeficiency in Hodgkin's disease in relation to second cancer development were studied. We suggest the establishment of a registry of leukemias and solid tumors developing in patients treated for Hodgkin's disease and other malignant neoplasms, possibly with detailed recording of immunocompetence data.
(Arch Intern Med 139:1131-1134, 1979)
O'Sullivan DD, Raghuprasad P, Ezdinli EZ. Solid Tumors Complicating Hodgkin's DiseaseA Report on Two Patients With Immunoglobulin Deficiency. Arch Intern Med. 1979;139(10):1131–1134. doi:10.1001/archinte.1979.03630470043015