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November 1979

Immune-Complex Deposition in the Eye in Systemic Lupus Erythematosus

Author Affiliations

From the Departments of Pediatrics (Dr Aronson), Pathology (Dr Ordoñez), and Ophthalmology (Drs Diddie and Ernest), University of Chicago-Pritzker School of Medicine and the Pediatric Nephrology Service, La Rabida Children's Hospital and Research Center, Chicago. Dr Ordoñez is now with the Department of Pathology, M. D. Anderson Hospital and Tumor Institute, Houston; Dr Diddie with the Department of Ophthalmology, University of Southern California, Los Angeles; and Dr Ernest with the Department of Ophthalmology, University of Wisconsin, Madison.

Arch Intern Med. 1979;139(11):1312-1313. doi:10.1001/archinte.1979.03630480084026

A patient with systemic lupus erythematosus (SLE) and lupus retinopathy showed resolution of subretinal edema documented with fluorescein angiography. Subsequently at autopsy, immunofluorescence studies disclosed ocular deposition of immunoglobulins in the vascular layer of choroid capillaries and basement membranes of ciliary processes and bulbar conjunctivas. To our knowledge, these findings represent the first reported documentation of probable immune-complex ocular vasculitis in lupus retinopathy using immunofluorescent techniques, and they support the hypothesis that lupus retinopathy is caused by immune complex deposition as are other manifestations of SLE.

(Arch Intern Med 139:1312-1313, 1979)