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February 1980

Clinical Application of the HLA-B27 Test in Rheumatic Diseases: A Current Perspective

Author Affiliations

From the Department of Medicine, Case Western Reserve University at Cleveland Metropolitan General Hospital.

Arch Intern Med. 1980;140(2):177-180. doi:10.1001/archinte.1980.00330140035015

• Testing for the histocompatibility antigen HLA-B27 has been suggested as a valuable diagnostic aid in patients with ankylosing spondylitis and associated spondyloarthropathies, and B27 typing is becoming more readily available commercially at a number of clinical pathology laboratories. A current evaluation of B27 typing as a diagnostic test is presented, together with some guidelines for the clinical application of this test in the diagnosis of certain rheumatic diseases.

(Arch Intern Med 140:177-180, 1980)