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February 1980

Transient Hyperthyroidism in Pregnancy

Author Affiliations

Morgantown, WVa

Arch Intern Med. 1980;140(2):283. doi:10.1001/archinte.1980.00330140141046

To the Editor.  —Spontaneous remission of hyperthyroidism and hypothyroidism following pregnancy has been associated with elevated levels of thyroid antimicrosomal antibodies during the time of altered thyroid function.1.2 A woman with transient hyperthyroidism during pregnancy was noted to have elevated thyroidstimulating immunoglobulin levels only when she was hyperthyroid, but negative antimicrosomal antibodies throughout her course.

Report of a Case.  — A 25-year-old woman was seen when she was three months pregnant. She had symptoms and signs of hyperthyroidism and a 50-g goiter. Past medical history was remarkable in that during each of her preceding three pregnancies she had noted a goiter and similar symptoms, all of which resolved after delivery.A suppression test with liothyronine sodium (Cytomel) resulted in an increase in serum thyroxine level from 15.6 to 19.5 μg/dL. She was given propranolol hydrochloride, 10 mg four times daily; this was continued until delivery of a normal infant