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March 1980

Cytarabine-Induced Anaphylaxis: Demonstration of Antibody and Successful Desensitization

Author Affiliations

From the Departments of Hematology-Oncology (Drs Rassiga, Forman, and Crum), and Allergy (Dr Schwartz), Veterans Administration Medical Center; and the Department of Medicine, Case Western Reserve School of Medicine, Cleveland.

Arch Intern Med. 1980;140(3):425-426. doi:10.1001/archinte.1980.00330150139034

• An anaphylactic episode occurred in a patient receiving cytarabine (Ara-C) for acute myeloid leukemia. Specific allergy of the patient to cytarabine was demonstrated in vivo by intradermal testing and in vitro by four-hour passive cutaneous anaphylaxis in guinea pigs. Desensitization to cytarabine was successfully performed. This case represents the first known report of both cytarabine anaphylaxis and densensitization, and provides immunologic evidence implicating an allergic reaction to cytarabine.

(Arch Intern Med 140:425-426, 1980)