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May 1980

Proliferative Glomerulonephritis With Crescent Formation in Behcet's Syndrome

Author Affiliations

From the Departments of Medicine and Pathology, University of Florida (Drs Olsson and Mars), and the Veterans Administration Hospital (Drs Gaffney, Alexander, and Fuller), Gainesville.

Arch Intern Med. 1980;140(5):713-714. doi:10.1001/archinte.1980.00330170129039

• Behçet's syndrome is a multisystem disease complex, the major manifestations of which are oral and genital ulcers, arthritis, uveitis, and skin eruptions. Less frequently, CNS disturbances, colitis, thrombophlebitis, large-vessel vasculitis, and myocarditis occur. If renal involvement does occur, it is usually manifested by asymptomatic microhematuria and/or proteinuria. Recently, renal amyloidosis and focal necrotizing glomerulonephritis with immune complex deposition have been described. We describe a patient with Behçet's syndrome who experienced diffuse proliferative glomerulonephritis with epithelial cell crescent formation in 75% of glomeruli examined. Immune complexes were not identified. Renal function, impaired on admission, improved with no therapy.

(Arch Intern Med 140:713-714, 1980)

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