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May 1980

Hypoglycemic Coma, Jaundice, and Pure RBC Aplasia Following Chlorpropamide Therapy

Author Affiliations

From the Department of Medicine, Dudley Road Hospital, Birmingham, England. Dr Gill is now with the University of Mannitoba, Winnipeg, Canada.

Arch Intern Med. 1980;140(5):714-715. doi:10.1001/archinte.1980.00330170130040

• Five weeks following the initiation of chlorpropamide therapy for diabetes mellitus, hypoglycemic coma, cholestatic jaundice, and RBC aplasia developed in a 41-year-old woman. Within 40 days of stopping the drug, she had made a complete recovery. To our knowledge, this is the first case in which these three complications of chlorpropamide have occurred simultaneously.

(Arch Intern Med 140:714-715, 1980)