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August 1980

Relationship Between Lipids and Occlusive Coronary Artery Disease

Author Affiliations

From the Division of Cardiology, Department of Medicine (Drs Zampogna and Luria and Mr Luria), and the Catheterization Laboratory (Dr Manubens), St Luke's Hospital, and Case Western Reserve University School of Medicine (Drs Luria and Manubens), Cleveland.

Arch Intern Med. 1980;140(8):1067-1069. doi:10.1001/archinte.1980.00330190079024

• Total cholesterol level, high-density lipoprotein (HDL) cholesterol level, and the ratio of total cholesterol/HDL cholesterol and triglyceride level were determined in 128 consecutive patients undergoing coronary arteriography for evaluation of chest pain. Greater than 50% occlusive coronary artery disease was more prevalent in patients with either a high total cholesterol level, triglyceride level, or total cholesterol/HDL ratio, or a low HDL cholesterol level. Closer analysis of the extent of occlusive coronary artery disease indicated that the HDL cholesterol level was a better predictor of coronary artery disease than total cholesterol or triglyceride levels. The ratio of total cholesterol/ HDL cholesterol, however, had a wider discrimination in identifying patients with both single-vessel or multivessel disease. This ratio should be a useful adjunct in assessing the risk of coronary artery disease.

(Arch Intern Med 140:1067-1069, 1980)