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September 1980

Postmenopausal Osteoporosis-Reply

Author Affiliations

Madrid, Spain

Arch Intern Med. 1980;140(9):1252. doi:10.1001/archinte.1980.00330200128046

It is, indeed, well known that an increase in growth hormone secretion is induced by estrogen; this happens chiefly in men,1 as is stated in the reference cited by Dr Pont.2 Marshall et al3 find lower estrogenic levels in postmenopausal osteoporotic women than in postmenopausal nonosteoporotic patients. On the other hand, Riggs et al4 do not find such a difference in the estrogenic levels among postmenopausal women with or without osteoporosis. In a recent study,5 we have not found notable bone mass variations in women with accentuated, moderate, or light degrees of estrogenic activity evaluated by means of vaginal cytology.

Short-term estrogen administration decreases the bone resorption,6 and it is believed that this is a consequence of the protectional role that, by decreasing the parathormone activity, the estrogens play on the bone.7-9 Long-term estrogen administration decreases the bone formation surface to one eighth of its pretreatment values.6 Growth hormone influences