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Isoniazid, as Sievers and Herrier note, functions as antivitamin B6. As they also note, it falls in the third of the three indications for treatment with megavitamin therapy, namely, the use of large doses of vitamins to counteract the biochemical damage produced by large doses of antivitamins. It should be pointed out that a large intravenous dose of pyridoxine constitutes acute therapy for acute toxic reaction caused by an antivitamin for pyridoxine. It is hoped that no reader of the letter by Sievers and Herrier will misinterpret it as suggesting that megadoses of pyridoxine are either safe for long-term use or effective in situations other than the three indications listed in the first paragraph of their article.
Victor Herbert. Megavitamin Therapy for Overdose-Reply. Arch Intern Med. 1980;140(12):1676. doi:10.1001/archinte.1980.00330230122037