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March 1981

Progressive Systemic Sclerosis and Nephrotic Syndrome: An Unusual Association Resulting in Postpartum Acute Renal Failure

Arch Intern Med. 1981;141(4):520-521. doi:10.1001/archinte.1981.00340040116029

A 27-year-old, full-term pregnant woman with progressive systemic sclerosis (PSS) came to the hospital with marked proteinuria and edema. Two days later, she gave birth to a normal baby. After delivery and during the next 48 hours, renal failure developed. A renal biopsy specimen disclosed findings characteristic of PSS, and immunofluorescence studies displayed nonspecific deposits of fibrinogen and complement. The patient's general condition deteriorated, with development of pericarditis and pulmonary failure; after several peritoneal dialysis treatments, a peritoneal infection developed, and the patient died of Gram-negative sepsis. The association of PSS and nephrotic syndrome is unusual.

(Arch Intern Med 1981;141:520-521)