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Article
April 1981

Acute Interstitial NephritisA Case Characterized by Increase in Serum IgG, IgM, and IgE Concentrations. Eosinophilia, and IgE Deposition in Renal Tubules

Arch Intern Med. 1981;141(5):679-681. doi:10.1001/archinte.1981.00340050125030
Abstract

• A case of acute interstitial nephritis with a distinct immunopathologic pattern was seen. The relevant findings included elevated levels of serum IgG, IgM, and IgE; persistent eosinophilia; prominent granular and electron-dense depositions of IgE and C3 in renal tubules, as demonstrated by direct immunofluorescent and electron microscopic procedures; persistent failure to demonstrate anti-basement membrane antibodies (both glomerular and tubular); and hypocomplementemia. The findings in our case suggest a type of acute interstitial nephritis with a somewhat different clinical outlook. In this respect, serial assays of complement components and IgE in serum and kidney tissue and determinations of circulating anti-basement membrane antibodies (both glomerular and tubular) may be of particular importance.

(Arch Intern Med 1981;141:679-681)

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