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May 1981

Propranolol IntoxicationA Severe Case Responding to Norepinephrine Therapy

Arch Intern Med. 1981;141(6):810-811. doi:10.1001/archinte.1981.00340060118032

• A patient with serious propranolol hydrochloride intoxication had seizures, hypotension, and was in a coma. Large amounts of propranolol were found in her serum and urine. Isoproterenol hydrochloride, a specific β-receptor agonist, was not effective in therapy. Hemodynamic improvement occurred with norepinephrine bitartrate. The half-life of propranolol was prolonged. She fully recovered.

(Arch Intern Med 1981;141:810-811)