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July 1981

Fulminant Lupus Pneumonitis With Acute Renal Failure and RBC Aplasia: Successful Management With Plasmapheresis and Immunosuppression

Author Affiliations

From the Departments of Haematology (Dr Isbister), Morbid Anatomy (Dr Ralston), Nephrology (Dr Hayes), and Intensive Therapy (Dr Wright), St Vincent's Hospital, Sydney, New South Wales, Australia. Dr Isbister is now with Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Arch Intern Med. 1981;141(8):1081-1083. doi:10.1001/archinte.1981.00340080117027

• Acute interstitial pneumonitis is a well-recognized, although rare, complication of systemic lupus erythematosus (SLE) that has been associated with a poor prognosis. Fulminant lupus pneumonitis, acute renal failure, and RBC hypoplasia occurred in a 14-year-old girl. The patient's condition was managed with large-volume plasmapheresis, dialysis, and immunosuppressive therapy. Her respiratory, renal, and hematologic changes all resolved, and response was maintained with cyclophosphamide and prednisolone therapy. Although serologic evidence of SLE persisted, clinically, the patient was well four years after the initial appearance of SLE. There are several acute pulmonary manifestations of SLE, and plasmapharesis may be useful in the management of some of these complications.

(Arch Intern Med 1981;141:1081-1083)