• Acute interstitial pneumonitis is a well-recognized, although rare, complication of systemic lupus erythematosus (SLE) that has been associated with a poor prognosis. Fulminant lupus pneumonitis, acute renal failure, and RBC hypoplasia occurred in a 14-year-old girl. The patient's condition was managed with large-volume plasmapheresis, dialysis, and immunosuppressive therapy. Her respiratory, renal, and hematologic changes all resolved, and response was maintained with cyclophosphamide and prednisolone therapy. Although serologic evidence of SLE persisted, clinically, the patient was well four years after the initial appearance of SLE. There are several acute pulmonary manifestations of SLE, and plasmapharesis may be useful in the management of some of these complications.
(Arch Intern Med 1981;141:1081-1083)
Isbister JP, Ralston M, Hayes JM, Wright R. Fulminant Lupus Pneumonitis With Acute Renal Failure and RBC AplasiaSuccessful Management With Plasmapheresis and Immunosuppression. Arch Intern Med. 1981;141(8):1081–1083. doi:10.1001/archinte.1981.00340080117027
Customize your JAMA Network experience by selecting one or more topics from the list below.