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November 1981

Glucose-Induced Hyperkalemia in Diabetic Subjects-Reply

Arch Intern Med. 1981;141(12):1722. doi:10.1001/archinte.1981.00340130160040

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Dr Rado's findings on serum potassium levels after the administration of glucose to normal and diabetic subjects are similar to ours. This was so despite the fact that two of his three diabetic subjects required no insulin and that physical activity was not controlled during the study.

The fact that pharmacologic amounts of desoxycorticosterone given two hours before the glucose load abolished GIH in Dr Rado's diabetic subjects is of interest but does not invalidate our conclusion that GIH is not abolished by a normal aldosterone response to increasing plasma potassium levels.

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