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January 1982

Thyrotrophin-Releasing Hormone Test: An Adverse Reaction

Author Affiliations

From the Departments of Obstetrics and Gynecology (Dr McFarland) and Medicine (Drs McFarland, Metzger, and Smith), Richland Memorial Hospital, University of South Carolina School of Medicine, Columbia; and the Department of Pediatrics (Dr Strickland), Spartanburg General Hospital, Medical University of South Carolina.

Arch Intern Med. 1982;142(1):132-133. doi:10.1001/archinte.1982.00340140134021

• The side effects of intravenous (IV) administration of protirelin (thyrotrophin-releasing hormone [TRH]) are usually mild and transient. The loss of consciousness and apical heart tones occurred in two young patients after protirelin injection. The mechanism for the reactions in these patients is not known, but the absence of heart sounds in the presence of no palpable pulse and no obtainable blood pressure should now be included among the adverse effects that may occur after administration of protirelin IV.

(Arch Intern Med 1982;142:132-133)

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