• The side effects of intravenous (IV) administration of protirelin (thyrotrophin-releasing hormone [TRH]) are usually mild and transient. The loss of consciousness and apical heart tones occurred in two young patients after protirelin injection. The mechanism for the reactions in these patients is not known, but the absence of heart sounds in the presence of no palpable pulse and no obtainable blood pressure should now be included among the adverse effects that may occur after administration of protirelin IV.
(Arch Intern Med 1982;142:132-133)
McFarland KF, Strickland AL, Metzger WT, Smith JS. Thyrotrophin-Releasing Hormone Test: An Adverse Reaction. Arch Intern Med. 1982;142(1):132–133. doi:10.1001/archinte.1982.00340140134021
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: