• A 22-year-old woman with systemic lupus erythematosus experienced generalized pruritus, shortness of breath, pleuritic chest pain, visual blurring, severe photophobia, a stiff neck, an occipital headache, and a temperature of 39.4 °C within one hour after taking sulindac (Clinoril). Findings from a CSF examination disclosed a notable elevation of protein and a polymorphonuclear pleocytosis. All symptoms disappeared within 24 hours. Inhibition of prostaglandin synthesis did not seem to be the mechanism of this adverse reaction, since the patient tolerated aspirin.
(Arch Intern Med 1982;142:165-166)
Ballas ZK, Donta ST. Sulindac-Induced Aseptic Meningitis. Arch Intern Med. 1982;142(1):165–166. doi:10.1001/archinte.1982.00340140167031
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: