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Clinical Observation
February 1982

Autoimmune Neutropenia in Hodgkin's Disease

Author Affiliations

From the Sections of Hematology and Medical Oncology, Departments of Medicine, Durham Veterans Administration Medical Center and Duke University Medical Center, Durham, NC (Drs Hunter and Logue); and the Department of Medicine, Asheville (NC) Veterans Administration Medical Center (Dr Joyner).

Arch Intern Med. 1982;142(2):386-388. doi:10.1001/archinte.1982.00340150186037

• A patient was profoundly neutropenic at the time of diagnosis of stage IIIB Hodgkin's disease. The neutropenia was not due to infection or bone marrow involvement by tumor. It did not respond to discontinuation of medication or to splenectomy, done for pathologic staging of Hodgkin's disease. The patient's serum contained abnormally increased granulocyte-binding antibody, which reacted with his own cells. The neutropenia resolved with high-dose prednisone therapy, and has not recurred after chemotherapy. Thus, immune neutropenia—as well as autoimmune hemolytic anemia and immune thrombocytopenic purpura—can be associated with Hodgkin's disease. Recognition and treatment of such immune processes assume major importance in planning cytotoxic therapy for the underlying malignancy.

(Arch Intern Med 1982;142:386-388)