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March 1982

Periodontal Infection in Patients With Acute Nonlymphocytic Leukemia: Prevalence of Acute Exacerbations

Author Affiliations

From the Department of Oral Diagnosis, Baltimore College of Dental Surgery, Dental School, University of Maryland at Baltimore (Drs Overholser and Peterson); and the Section of Infection and Microbiological Research, Baltimore Cancer Research Center, University of Maryland School of Medicine (Ms Williams and Dr Schimpff).

Arch Intern Med. 1982;142(3):551-554. doi:10.1001/archinte.1982.00340160131025

From the initiation of chemotherapy until attainment of complete remission, 22 newly diagnosed, hospitalized patients with acute nonlymphocytic leukemia were studied for the prevalence of periodontal disease at admission and for acute exacerbations during myelosuppressive chemotherapy. Consistent with a normal population, all patients had asymptomatic periodontal disease at admission. In these 22 patients, 47 acute infections developed, including 13 of periodontal origin. All but three acute periodontal infections occurred during pronounced granulocytopenia (< 100 granulocytes per microliter). Although signs and symptoms of inflammation were minimal, all 13 episodes were associated with pain and fever. Asymptomatic periodontal disease is readily overlooked but can be easily diagnosed by thorough clinical and roentgenographic examination. Its occurrence in patients with acute leukemia and its acute exacerbation during granulocytopenia indicate that this oral infection is associated with considerable morbidity during the treatment of acute nonlymphocytic leukemia.

(Arch Intern Med 1982;142:551-554)

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