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April 1982

Combined Vitamin D Parathyroid Defect in Thalassemia Major

Author Affiliations

From the Department of Medicine, Nassau Hospital, Mineola, NY (Drs Aloia and Yeh); Mercy Hospital, Rockville Center, NY (Dr Zaino); and the Health Sciences Center State University of New York at Stony Brook (Drs Aloia, Yeh, and Ostuni).

Arch Intern Med. 1982;142(4):831-832. doi:10.1001/archinte.1982.00340170191029

A 17-year-old girl with thalassemia major experienced tetany. The serum calcium level was 5.5 mg/dL, and the phosphorus level was 6.3 mg/dL. Serum levels of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25-OHD) were subnormal at 125 pg/mL and 8.1 ng/mL, respectively. As a result of these findings, serum 25-OHD and PTH levels were measured in an additional 12 patients with thalassemia major. Low levels of both 25-OHD and PTH were found frequently. An increase in serum 25-OHD levels was noted in each of four patients who were examined after iron chelation therapy.

(Arch Intern Med 1982;142:831-832)