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April 1982

Morphine-Induced Immune Thrombocytopenia

Author Affiliations

From the Department of Medicine, the Divisions of Hematology (Drs Cimo and Moake) and Hypertension (Dr Hammond), the University of Texas Medical School at Houston.

Arch Intern Med. 1982;142(4):832-834. doi:10.1001/archinte.1982.00340170192030

Sudden thrombocytopenia that was temporally related to the administration of morphine sulfate developed in a 23-year-old woman. A morphine-dependent platelet antibody was found in her serum by chromic chloride Cr 51 platelet lysis. The antibody was complement dependent, present in the IgG immunoglobulin fraction, and its drug-dependent platelet lytic activity was demonstrable with several narcotic analgesics in addition to morphine. The antibody activity declined over an eight-month period following recovery from thrombocytopenia. To our knowledge, morphine-induced immune thrombocytopenia has not previously been described.

(Arch Intern Med 1982;142:832-834)