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Original Investigation
May 1982

Familial Bartter's Syndrome

Author Affiliations

From the Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku, Osaka, Japan. Dr Nugent is now with the University of Arizona, Tucson.

Arch Intern Med. 1982;142(5):906-908. doi:10.1001/archinte.1982.00340180064015

Two sisters were found to have Bartter's syndrome. Both had hypokalemia, hyperreninemia, normal BPs, and decreased pressor responses to angiotensin II. During a water diuresis, patient 1 had an abnormally low distal tubular fractional reabsorption of chloride initially, but this normalized after hypokalemia was corrected for one year. Patient 2 had no demonstrable defect in chloride transport. Hypokalemia in Bartter's syndrome may be caused by some hereditary mechanisms other than defective reabsorption of chloride in the distal tubules.