• The effect of low doses (25 mg three times a day) of captopril was evaluated in 16 patients with mild to moderate essential hypertension, previously uncontrolled by hydrochlorothiazide. After a no-treatment period, mean eight-hour seated diastolic blood pressure (SDBP, mm Hg) was 103 ± 5 on placebo, 95 ± 8 after a single dose of captopril, 96 ± 4 after two weeks of captopril alone, and 90 ± 6 after its combination with hydrochlorothiazide. Though nine patients had at least a 10% fall in SDBP after the initial dose of captopril, only three had a comparable fall after two weeks; after captopril and hydrochlorothiazide, however, 12 patients had such a response. Captopril decreased mean angiotensin-converting enzyme activity and plasma aldosterone, though to a lesser extent with continued therapy. Because its side effects appear dose related, low doses of captopril combined with a diuretic are effective and may be better tolerated.
(Arch Intern Med 1982;142:1098-1101)
Vlasses PH, Rotmensch HH, Swanson BN, Mojaverian P, Ferguson RK. Low-Dose Captopril: Its Use in Mild to Moderate Hypertension Unresponsive to Diuretic Treatment. Arch Intern Med. 1982;142(6):1098–1101. doi:10.1001/archinte.1982.00340190054010
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