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August 1982

Classic Gout in Hageman Factor (Factor XII) Deficiency

Author Affiliations

From the Atherosclerosis Program, Rehabilitation Institute of Chicago (Dr Green); the Departments of Medicine, Veterans Administration Lakeside Hospital and Northwestern University Medical School, Chicago (Drs Green, Arsever, and Grumet); and Case Western Reserve University School of Medicine, Cleveland (Dr Ratnoff).

Arch Intern Med. 1982;142(8):1556-1557. doi:10.1001/archinte.1982.00340210154028

A 62-year-old man with a typical history of gout was admitted to the hospital with left-sided hemiplegia. His serum uric acid level was 10.3 mg/dL, his partial thromboplastin time was 198 s, and his Hageman factor (factor XII) coagulant activity and antigen were less than 1% of normal. Aspiration of synovial fluid from his inflamed knee disclosed urate crystals and abundant leukocytes but an absence of Hageman factor antigen. The presence of acute gouty arthritis in a patient with Hageman trait challenges the role of Hageman factor in the pathogenesis of gouty arthropathy.

(Arch Intern Med 1982;142:1556-1557)