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September 1982

Carcinoid Tumor of the Gastrointestinal Tract With Metastases to the Brain

Author Affiliations

From the Departments of Internal Medicine (Dr Schiffman) and Pathology (Ms Barnard), Yale University School of Medicine and Yale-New Haven (Conn) Hospital. Ms Barnard is now with New England Deaconess Hospital, Boston.

Arch Intern Med. 1982;142(9):1717-1719. doi:10.1001/archinte.1982.00340220141023

• A 56-year-old woman with carcinoid tumor of the gastrointestinal tract, which was metastatic to the mesenteric lymph nodes, was seen four months after bowel resection with new neurologic findings. Results of an initial examination suggested infection with mycobacteria or fungi, but the condition of the patient deteriorated, and she died after antituberculous and antifungal therapy was begun. She never suffered from carcinoid syndrome, and 5-hydroxyindoleacetic acid and 5-hydroxytryptamine were not detected in blood samples. A postmortem examination disclosed widespread metastases of carcinoid tumor, including invasion of the cerebral hemispheres. In this article, CNS metastasis of carcinoid tumors is discussed as well as the possibility that drug interactions may have contributed to some of the patient's neurologic findings.

(Arch Intern Med 1982;142:1717-1719)