[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
November 1982

Subtle Cobalamin Malabsorption in a Vegan Patient: Evolution Into Classic Pernicious Anemia With Anti-intrinsic Factor Antibody

Author Affiliations

From the Department of Medicine, University of Southern California (USC) School of Medicine and the Los Angeles County-USC Medical Center.

Arch Intern Med. 1982;142(12):2206-2207. doi:10.1001/archinte.1982.00340250172029

• Classic pernicious anemia with abnormal Schilling test results developed in a previously described vegan patient who had coexisting subtle cobalamin malabsorption (demonstrable by abnormal ovalbumin-cobalamin absorption test results but normal Schilling test results). This suggests that the ovalbumin-cobalamin absorption test or a modified version may serve as a prodromal phenomenon to identify patients at risk for developing pernicious anemia. The patient's transformation was also accompanied by the appearance of serum anti-intrinsic factor antibody. A modified assay retrospectively detected this antibody a year earlier than did the standard assay, indicating that such modification enhances the sensitivity of this useful test.

(Arch Intern Med 1982;142:2206-2207)