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November 1982

Aplastic Crisis due to Extensive Bone Marrow Necrosis in Sickle Cell Disease

Author Affiliations

From the Departments of Medicine (Drs Pardoll, Rodeheffer, and Charache) and Laboratory Medicine (Drs Smith and Charache), The Johns Hopkins Medical Institutions, Baltimore.

Arch Intern Med. 1982;142(12):2223-2225. doi:10.1001/archinte.1982.00340250189034

• A lengthy aplastic crisis, manifest by pancytopenia and fever, was observed in a young woman with sickle cell β°-thalassemia. Bone marrow aspirates and biopsy specimens showed marrow necrosis, and reticuloendothelial scans showed widespread abnormalities consistent with marrow infarction. Physical damage to erythropoietic tissue as well as arrest of erythropoiesis can cause acute erythroblastopenia in patients with sickle cell anemia.

(Arch Intern Med 1982;142:2223-2225)