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January 1983

Normal Platelet Function After Therapy for Acute Lymphocytic Leukemia

Author Affiliations

From the Leukemia-Lymphoma Service, St Jude Children's Research Hospital (Drs Pui and Jackson), the Department of Medicine, Division of Hematology, University of Tennessee Center for the Health Sciences (Dr Chesney), and the Department of Pathology, Baptist Memorial Hospital (Dr Chesney), Memphis.

Arch Intern Med. 1983;143(1):73-74. doi:10.1001/archinte.1983.00350010077013

• The aggregation responses of platelets from 19 patients who had completed treatment of acute lymphocytic leukemia (ALL) and had remained in remission for two months to 4.8 years were studied both in vitro and in vivo. Responses to 0.5μM adenosine diphosphate (ADP), epinephrine, and collagen were all normal. One child had irreversible platelet aggregation to 0.1μM ADP, a concentration that only elicited a primary aggregation response from control platelets. The mean platelet-aggregate ratio was normal. We conclude that platelet defects, although a possible late effect of ALL or its chemotherapy, do not occur with any appreciable frequency in long-term survivors.

(Arch Intern Med 1983;143:73-74)

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