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March 1983

Exogenous Hyperthyroidism With Osteoporosis

Author Affiliations

From the Division of Bone and Mineral Metabolism, Department of Medicine (Drs Fallon, Perry, Teitelbaum, and Avioli and Ms Droke), and the Department of Pathology and Laboratory Medicine (Drs Fallon and Teitelbaum and Ms Bergfeld), the Jewish Hospital of St Louis, Washington University School of Medicine. Dr Fallon is now with the Hospital of the University of Pennsylvania, Philadelphia.

Arch Intern Med. 1983;143(3):442-444. doi:10.1001/archinte.1983.00350030052010

• Symptomatic osteopenia accompanied by subclinical hyperthyroidism developed in three women who were receiving excess thyroid hormone medication. Excessive thyroid replacement therapy resulted in mild hypercalcemia, hyperphosphatemia, and hyperphosphatasemia associated with diffuse skeletal demineralization and multiple fractures. Nondecalcified sections of double tetracycline-labeled iliac crest bone showed an accelerated rate of bone turnover with marked osteoclastosis and resorption of the cortical as well as the trabecular bone, typical of endogenous hyperthyroidism. Since thyroid hormones are among the most frequently prescribed medications, bone loss caused by exogenous hyperthyroidism may be more common than previously recognized.

(Arch Intern Med 1983;143:442-444)

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