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March 1983

Pure RBC Aplasia and Myasthenia Gravis: Coexistence of Two Diseases Associated With Thymoma

Arch Intern Med. 1983;143(3):543-546. doi:10.1001/archinte.1983.00350030157027

• Pure RBC aplasia (PRCA) and myasthenia gravis (MG) are occasionally associated with thymoma, although the occurrence of all three in a single patient is rare. We describe a patient in whom PRCA and MG occurred in conjunction with the presence of serum autoantibodies, evidence for a serum inhibitor of erythropoiesis, and elevation of circulating thymosin α1. Although a thymoma could not be detected before death, postmortem examination of the mediastinum found scattered cells within a nodule, suggestive of a lymphoepithelial thymic neoplasm.

(Arch Intern Med 1983;143:543-546)