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March 1983

Pure RBC Aplasia and Myasthenia Gravis: Coexistence of Two Diseases Associated With Thymoma

Author Affiliations

From the Departments of Pathology (Mr Socinski and Dr Frankel), Medicine (Mr Socinski and Drs Ershler, Albertini, Krawitt, and Burns), and Neurology (Dr Ciongoli), University of Vermont College of Medicine, Burlington, and the Department of Medicine, Montefiore Hospital, University of Pittsburgh (Dr Mangan).

Arch Intern Med. 1983;143(3):543-546. doi:10.1001/archinte.1983.00350030157027

• Pure RBC aplasia (PRCA) and myasthenia gravis (MG) are occasionally associated with thymoma, although the occurrence of all three in a single patient is rare. We describe a patient in whom PRCA and MG occurred in conjunction with the presence of serum autoantibodies, evidence for a serum inhibitor of erythropoiesis, and elevation of circulating thymosin α1. Although a thymoma could not be detected before death, postmortem examination of the mediastinum found scattered cells within a nodule, suggestive of a lymphoepithelial thymic neoplasm.

(Arch Intern Med 1983;143:543-546)

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