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April 1983

Cimetidine-Induced Interstitial Nephritis With Response to Prednisone Therapy

Author Affiliations

From the Departments of Medicine (Drs Kaye, Passero, and Solomon) and Pathology (Dr Johnson), Roger Williams General Hospital, and Brown University (Drs Kaye, Passero, Solomon, and Johnson), Providence, RI.

Arch Intern Med. 1983;143(4):811-812. doi:10.1001/archinte.1983.00350040201031

• Acute renal failure developed in a patient after she received cimetidine therapy. A renal biopsy specimen showed acute interstitial nephritis. Withdrawal of cimetidine therapy led to improvement of renal function. Rechailenge with cimetidine occurred during prednisone therapy. Renal function continued to improve, but worsened when the treatment with these steroids was discontinued.

(Arch Intern Med 1983;143:811-812)

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