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May 1983

Sequestered Substernal Goiter

Author Affiliations

From the Thyroid Unit (Drs Ladenson and Ridgway), Department of Medicine, Massachusetts General Hospital, and the Departments of Surgery (Dr Vineyard) and Pathology (Dr Pinkus), Brigham and Women's Hospital, Boston.

Arch Intern Med. 1983;143(5):1015-1017. doi:10.1001/archinte.1983.00350050179031

• A young woman with a normally located and only subtly nodular thyroid gland in the neck was found to have a clinically distinct and radioisotopically "cold" anterior mediastinal mass, which proved to be a benign colloid adenoma. While this constellation of findings usually suggests the presence of a nonthyroidal neoplasm, eg, lymphoma, thymoma, or teratoma, our case illustrates that sequestered benign nodular goiter should also be considered in the differential diagnosis. Clinical clues, such as a nodular thyroid gland, movement of the mass with deglutition, and a family history of nodular goiter, should suggest this possibility. A characteristic computed tomographic appearance may also prove useful in recognition of this rare disorder.

(Arch Intern Med 1983;143:1015-1017)