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May 1983

Cushing's Disease in a Patient With a 'Nonfunctioning' Pituitary Tumor: Spontaneous Development and Remission

Author Affiliations

From the Metabolic Research Unit (Drs Gogel, Salber, Tyrrell, and Findling) and the Departments of Medicine (Dr Tyrrell) and Neurological Surgery (Dr Rosenblum), University of California, San Francisco. Dr Gogel is now with the State University of New York, Stony Brook; Dr Findling is now with the Medical College of Wisconsin, St Luke's Hospital, Milwaukee.

Arch Intern Med. 1983;143(5):1040-1042. doi:10.1001/archinte.1983.00350050206041

• A 40-year-old woman had visual loss and a large nonfunctioning pituitary tumor. After partial surgical resection and radiation treatment, clinical and biochemical evidence of Cushing's disease developed. The pituitary source of her adrenocorticotropic hormone hypersecretion was documented on selective venous sampling. After 18 months of medical therapy with metyrapone and aminoglutethimide, the patient experienced a spontaneous remission of her hypercortisolism. A "nonfunctioning" pituitary tumor has a hypersecretory potential.

(Arch Intern Med 1983;143:1040-1042)

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