• A 40-year-old woman had visual loss and a large nonfunctioning pituitary tumor. After partial surgical resection and radiation treatment, clinical and biochemical evidence of Cushing's disease developed. The pituitary source of her adrenocorticotropic hormone hypersecretion was documented on selective venous sampling. After 18 months of medical therapy with metyrapone and aminoglutethimide, the patient experienced a spontaneous remission of her hypercortisolism. A "nonfunctioning" pituitary tumor has a hypersecretory potential.
(Arch Intern Med 1983;143:1040-1042)
Gogel EL, Salber PR, Tyrrell JB, Rosenblum ML, Findling JW. Cushing's Disease in a Patient With a 'Nonfunctioning' Pituitary Tumor: Spontaneous Development and Remission. Arch Intern Med. 1983;143(5):1040–1042. doi:10.1001/archinte.1983.00350050206041
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.