Medicine is partly an art and partly a science. Its artistic aspects will always remain important, since medical activity encompasses human relationships between suffering and helping human beings. However, many of us ardently wish there was more science in clinical medicine for the good of our patients and the prestige of our trade. Unfortunately, a lack of knowledge is not the only reason why science so often seems absent from clinical practice. The evaluation of clinical interventions with controlled and, preferably, randomized clinical trials (RCTs) and the courage to accept the results of these properly designed and conducted studies (no matter how distasteful they may be) would improve the image of medicine as a science. Randomized clinical trials are particularly critical in complex situations when only circumstantial (or animal) evidence suggest that treatment A is better than treatment B, although the safety and feasibility of A v B has not