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June 1983

Acute Nonlymphocytic Leukemia and Acute Aplastic Anemia: The Simultaneous Occurrence in Marital Partners

Author Affiliations

From the Division of Hematology-Oncology, the Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville.

Arch Intern Med. 1983;143(6):1156-1158. doi:10.1001/archinte.1983.00350060080013

• A young husband and wife couple presented simultaneously with aplastic anemia and acute myelomonocytic leukemia, respectively. No etiologic agent or exposure was identified. With appropriate therapy, the wife achieved a complete remission and the husband has had a good response. Potential etiologic environmental factors known to cause both disorders are discussed. A single causative agent may induce stem-cell changes in genetically dissimilar persons and produce a spectrum of pathologic features ranging from aplastic anemia to acute leukemia.

(Arch Intern Med 1983;143:1156-1158)