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This recent publication responds to a pressing need to review and summarize the vast amount of experimental and clinical information acquired in the past decade regarding the single most important rhythm disturbance in man. To meet the challenge, Dr Josephson invited the contributions of authors chosen from the University of Pennsylvania, as well as from several other institutions inside and outside the United States, who are renowned for their pioneering work in the field of ventricular arrhythmias. The final product is a comprehensive yet concise document containing a series of high-quality review chapters, abundantly illustrated and accompanied by extensive bibliographies. The material presented extends from basic experimental observations to the immediately applicable clinical information. The contributions of Wit on experimental infarction and Corr and Sobel on the biochemical and metabolic aspects of ventricular arrhythmias, describing some of the most recent basic mechanistic observations made in the whole heart and at