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September 1983

Thalassemia Among Chinese-BostoniansUsefulness of the Hemoglobin H Preparation

Arch Intern Med. 1983;143(9):1713-1715. doi:10.1001/archinte.1983.00350090091015

• Microcytosis was noted in 14.7% of the complete blood cell count reports of Chinese subjects in a Boston Chinatown health center. One hundred forty-nine of these subjects' conditions were further evaluated by hemoglobin electrophoresis, Hb H inclusion bodies preparation, Hb A2 quantitation, and ferritin assay. Ninety-one cases of α-thalassemia-1 trait and 49 cases of β-thalassemia trait were diagnosed. In this study population, the prevalence of thalassemia trait and of iron deficiency resulting in microcytosis was 13.8% and 3.4%, respectively. The Hb H preparation was found to be clinically useful and reliable for detecting α-thalassemia-1 trait in Chinese carriers, after the exclusion of iron deficiency and β-thalassemia by routine studies.

(Arch Intern Med 1983;143:1713-1715)