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September 1983

Lymphocytic Hypophysitis: Associated With Antiparietal Cell Antibodies and Vitamin B12 Deficiency

Author Affiliations

From the Departments of Medicine (Drs Mazzone and Ensinck) and Neurosurgery (Dr Kelly), University of Washington School of Medicine, Seattle. Dr Mazzone is now with Michael Reese Hospital and Medical Center, Chicago.

Arch Intern Med. 1983;143(9):1794-1795. doi:10.1001/archinte.1983.00350090176032

• Lymphocytic hypophysitis has been recognized as a distinct clinicopathologic entity. It is a cause of hypopituitarism in the postpartum period and is believed to have an autoimmune pathogenesis. We treated a patient with lymphocytic hypophysitis with two unique features. First, this patient had had a prolactin level of 101 ng/mL (normal, 0 to 25 ng/mL). To our knowledge, this degree of elevation has not been previously reported and is a level that might cause confusion with prolactin-secreting pituitary adenomas. Second, this patient had positive titers for antiparietal cell antibodies in conjunction with a low vitamin B12 level and anemia. To our knowledge, this is the first report of a clinically important autoantibody to extrapituitary tissue in a living patient with lymphocytic hypophysitis.

(Arch Intern Med 1983;143:1794-1795)

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