• Lymphocytic hypophysitis has been recognized as a distinct clinicopathologic entity. It is a cause of hypopituitarism in the postpartum period and is believed to have an autoimmune pathogenesis. We treated a patient with lymphocytic hypophysitis with two unique features. First, this patient had had a prolactin level of 101 ng/mL (normal, 0 to 25 ng/mL). To our knowledge, this degree of elevation has not been previously reported and is a level that might cause confusion with prolactin-secreting pituitary adenomas. Second, this patient had positive titers for antiparietal cell antibodies in conjunction with a low vitamin B12 level and anemia. To our knowledge, this is the first report of a clinically important autoantibody to extrapituitary tissue in a living patient with lymphocytic hypophysitis.
(Arch Intern Med 1983;143:1794-1795)
Mazzone T, Kelly W, Ensinck J. Lymphocytic Hypophysitis: Associated With Antiparietal Cell Antibodies and Vitamin B12 Deficiency. Arch Intern Med. 1983;143(9):1794–1795. doi:10.1001/archinte.1983.00350090176032
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