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September 1983

Successful Ketoconazole Treatment of Protothecosis With Ketoconazole-Associated Hepatotoxicity

Author Affiliations

From the Departments of Medicine (Drs Pegram and Kerns) and Pathology (Drs Wasilauskas and Scharyj and Mr Hampton), Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC; and the Surry Orthopedic Associates, Mount Airy, NC (Dr Burke).

Arch Intern Med. 1983;143(9):1802-1805. doi:10.1001/archinte.1983.00350090184035

• A 46-year-old woman had a chronic, unresponsive wrist infection that was proved to be due to the algaelike organism Prototheca wickerhamii. Treatment with ketoconazole resulted in prompt improvement and ultimate healing. Therapy was complicated by hepatitis that was ketoconazole-related. Ketoconazole may be effective and easily administered therapy for this generally unresponsive infection.

(Arch Intern Med 1983;143:1802-1805)

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