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October 1983

Antibodies to Herpes Simplex Type 1 in Patients With Active Duodenal Ulcer

Author Affiliations

From the Departments of Medicine (Drs Rand, Guild, and McGuigan), Pathology (Dr Rand), and Immunology and Medical Microbiology (Drs Rand and McGuigan), University of Florida College of Medicine, Gainesville; the Gainesville Veterans Administration Medical Center, (Dr Rand); and the Department of Medicine, Milton S. Hershey Medical Center, Hershey, Pa (Dr Koch). Dr Jacobson is in private practice in Stuart, Fla. Dr Cottrell is in private practice in Orlando, Fla.

Arch Intern Med. 1983;143(10):1917-1920. doi:10.1001/archinte.1983.00350100085019

• One hundred seventy-two patients requiring upper gastrointestinal tract endoscopy were examined prospectively for evidence of herpes simplex virus type 1 (HSV-1) infection. No viruses were recovered from active ulcers (11 with duodenal and eight with gastric ulcers). Using both enzyme-linked immunosorbent assay (ELISA) and standard complement fixation methods, patients with endoscopically proved active duodenal ulcer had significantly higher mean serum antibody levels to HSV-1 (but not to cytomegalovirus) than those without evidence of peptic ulcer. Neither patients with a history of or evidence of past peptic ulcer nor those with active gastric ulcer had higher serum antibody levels to HSV-1 compared with subjects without ulcers. These data provide support for an association between active duodenal ulcer and HSV-1 infection, the nature of which is not defined by these studies.

(Arch Intern Med 1983;143:1917-1920)

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