• The postabsorptive urinary total (T), dialyzable (D), and nondialyzable (ND) hydroxyproline (HYPRO) tests were evaluated to determine whether the patterns of excretion varied according to the predominance of osteoblastic v osteolytic bone involvement in 58 patients with neoplastic disease. In patients with osteolytic lesions from multiple myeloma, elevated T and D levels with normal ND HYPRO values were observed, along with elevated D/ND ratios. In prostate cancer, the T, D, and ND values were all elevated and the D/ND ratio was normal. Patients with Hodgkin's disease had elevated T, D, and ND HYPRO levels, and the D/ND ratio was in the range of patients with prostate cancer. The data suggest that these collagen markers may be useful in the long-term evaluation of these neoplasms in patients.
(Arch Intern Med 1983;143:1925-1927)
Niell HB, Palmieri GM, Neely CL, Maxwell TA, Hopkins SC, Soloway MS. Total, Dialyzable, and Nondialyzable Postabsorptive Hydroxyproline: Values in Patients With Cancer. Arch Intern Med. 1983;143(10):1925–1927. doi:10.1001/archinte.1983.00350100097020
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