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November 1983

Reversible Renal Failure

Author Affiliations

Clinica Medica 2 Istituto di Medicina Clinica Università di Padova Via Giustiniani 2 35128 Padova, Italy

Arch Intern Med. 1983;143(11):2215. doi:10.1001/archinte.1983.00350110209048

To the Editor.  —We read with interest the article by Chrysant et al in the March Archives (1983;143:437-441). We also recently observed the development of acute reversible renal failure in a patient.

Report of a Case.  —A 30-year-old woman had high-grade bilateral renal artery stenosis. She was judged inoperable in December 1976, and she was treated conservatively for four years with 10 mg of minoxidil three times a day, 40 mg of propranolol hydrochloride three times a day, 10 mg of amiloride hydrochloride, and 50 mg/day of hydrochlorothiazide. With this drug regimen her BP ranged between 140 to 160 mm Hg (systolic) and 85 to 95 mm Hg (diastolic) and renal function test results were in the normal range. In January 1983, because of severe hirsutism, the minoxidil dosage was tapered to 2.5 mg three times a day, and therapy with captopril (25 mg twice a day) was added. Seven